A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of vegetables induces enzymes of xenobiotic metabolism and thereby accelerates the metabolic disposal of xenobiotics. Induction of phase II detoxication enzymes, such as quinone reductase [NAD(P)H:(quinone-acceptor) oxidoreductase, EC 1.6.99.2] and glutathione S-transferases (EC 2.5.1.18) in rodent tissues affords protection against carcinogens and other toxic electrophiles. To determine whether enzyme induction is responsible for the protective properties of vegetables in humans requires isolation of enzyme inducers from these sources. By monitoring quinone reductase induction in cultured murine hepatoma cells as the biological assay, we have isolated and identified (-)-1-isothiocyanato-(4R)这12条期货股票交易制胜法则 -(methylsulfinyl)butane [CH3-SO-(CH2)4-NCS, sulforaphane] as a major and very potent phase II enzyme inducer in SAGA broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, like other anticarcinogenic isothiocyanates, and induces phase II enzymes selectively without the induction of aryl 这12条期货股票交易制胜法则 hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). To 这12条期货股票交易制胜法则 elucidate the structural features responsible for the high inducer potency of sulforaphane, we synthesized racemic sulforaphane and analogues differing in the oxidation state of sulfur and the number of methylene groups: CH3-SOm-(CH2)n-NCS, where m = 0, 1, or 2 and n = 3, 4, or 5, and measured their inducer potencies in murine hepatoma cells. Sulforaphane is the most potent inducer, and the presence of oxygen on sulfur enhances potency. Sulforaphane and its sulfide and sulfone analogues induced both quinone reductase and glutathione transferase activities in several mouse tissues. The induction 这12条期货股票交易制胜法则 of detoxication enzymes by sulforaphane may be a significant component of the anticarcinogenic action of broccoli.
Similar articles
Prochaska HJ, Santamaria AB, Talalay P. Prochaska HJ, et al. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2394-8. doi: 10.1073/pnas.89.6.2394. Proc Natl Acad Sci U S A. 1992. PMID: 1549602 Free PMC article.
Posner GH, Cho CG, Green JV, Zhang Y, Talalay P. Posner GH, et al. J Med Chem. 1994 Jan 7;37(1):170-6. doi: 10.这12条期货股票交易制胜法则 1021/jm00027a021. J Med Chem. 1994. PMID: 8289191
Gerhäuser C, You M, Liu J, Moriarty RM, Hawthorne M, Mehta RG, Moon RC, Pezzuto JM. Gerhäuser C, et al. Cancer Res. 1997 Jan 15;57(2):272-8. Cancer Res. 1997. PMID: 9000567
Talalay P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y. Talalay P, et al. Toxicol Lett. 1995 Dec;82-83:173-9. doi: 10.1016/0378-4274(95)03553-2. Toxicol Lett. 1995. PMID: 8597048 Review.
James D, Devaraj S, Bellur P, Lakkanna S, Vicini J, Boddupalli S. James D, et al. Nutr Rev. 2012 Nov;70(11):654-65. doi: 10.1111/j.1753-4887.2012.00532.x. Epub 2012 Oct 12. Nutr Rev. 2012. PMID: 23110644 Review.
Cited by
Panieri E, Pinho SA, Afonso GJM, Oliveira PJ, Cunha-Oliveira T, Saso L. Panieri E, et al. Cells. 2022 Aug 4;11(15):2401. doi: 10.3390/cells11152401. Cells. 2022. PMID: 35954245 Free PMC article. Review.
Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP, Sabbagh MF, Shin JY, Yang W, Snowman AM, Albacarys LK, Moghekar A, Pardo-Villamizar CA, Luciano M, Huang J, Bettegowda C, Kwatra SG, Dong X, Lim M, Snyder SH. Vasavda C, et al. Sci Adv. 2022 这12条期货股票交易制胜法则 Aug 5;8(31):eabo5633. doi: 10.1126/sciadv.abo5633. Epub 2022 Aug 3. Sci Adv. 2022. PMID: 35921423 Free PMC article.
Fasipe B, Li S, Laher I. Fasipe B, et al. Sports Med Health Sci. 2021 May 4;3(2):70-79. doi: 10.1016/j.smhs.2021.04.002. eCollection 2021 Jun. Sports Med Health Sci. 2021. PMID: 35782161 这12条期货股票交易制胜法则 Free PMC article. Review.
Kahremany S, Hofmann L, Gruzman A, Dinkova-Kostova AT, Cohen G. Kahremany S, et al. Free Radic Biol Med. 2022 Aug 1;188:262-276. doi: 10.1016/j.freeradbiomed.2022.06.238. Epub 2022 Jun 23. Free Radic Biol Med. 2022. PMID: 35753587 Free PMC article. Review.
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Eisenstein A, et al. Immunity. 2022 Jun 14;55(6):1082-1095.e5. doi: 10.1016/j.immuni.2022.04.015. Epub 2022 May 18. Immunity. 2022. PMID: 35588739
我要这盛世美颜有何用
作品简评:
八十年前撂地卖艺的相声艺人齐涉江,借尸还魂在八十年后一名娱乐圈偶像身上,齐涉江顶着这副盛世美颜,却坚持要干老本行:说相声。可就凭这张脸,谁也不信他是说相声的,谁也不信他不靠脸吃饭。
本文以主角齐涉江的逆袭之路为主线,描绘他如何利用自己所学大显身手,不但一洗花瓶之耻,更将传统曲艺、失传曲种再次带回大众眼前,登上事业高峰,找到自己与新时空的联系。故事简单轻松,但节奏控制的非常好,引人入胜。各人物形象鲜明性格突出,全文苏爽中不失幽默诙谐,是一本据说可以“听”的轻娱乐佳作。
EXCEL的公式排列问题A1---A12中分别是12个数字,这12个数字中有重复而且杂乱无序,求 A13=在这12个数字
EXCEL的公式排列问题
A1---A12中分别是12个数字,这12个数字中有重复而且杂乱无序,求 A13=在这12个数字中按照从小到大顺序排名第八的数字(重复的数字按一个算).托REDSTARW同志的大力支持.已经得到正确答案.可是这是列的计算,如果换成行计算呢?公式又是什么呢?
我的意思是,问题是A1---N1分别是12个数字,求 P1=在这12个数字中按照从小到大顺序排名第八的数字(重复的数字按一个算)
期待您的赐教@谢谢
1)感谢LEVI-WZH的提醒,不过不是你想的那么简单,就是因为验证过不行偶才提问的,
2)感谢朱荟催非的回答,不过,验证过您提供的公式后,发现结果很匪夷所思,比如我将1-13个数字打乱次序填入了A1--O1,其中5我写了3个,9写了2个,6空缺,结果输入公式后,按从小到大排列在第五位的应该是5,结果却是7,排在第六位的应该是8,结果却是7,排在第七位的应该是10,结果却是8.所以,你的公式应该是有出入的,
3)感谢HANYISKIP的回答,不过您的公式不是我要的问题,
Inspired by the human element to advance cell therapy
The courage patients show 这12条期货股票交易制胜法则 is what propels us forward
More than 10 pipeline agents
Collective experience and passion for cell therapy
A global manufacturing footprint
See what inspires us to deliver what's next
United States Global Headquarters 2101 Cottontail Lane Somerset, NJ 08873, USA
+1 (732) 317-5050
Piscataway Location 10 Knightsbridge Road Piscataway, NJ 08854, USA
China
No. 6 Building, Life Science TechTown
568 Longmian Avenue
Jiangning District
Nanjing 211100, China
Ireland
10A Ballymoss Road
Sandyford Business Park
Dublin 18, D18 T934, Ireland
Belgium